The epigenetic regulation of synaptic genes contributes to the etiology of autism-Reference-Cited by-同舟云学术

The epigenetic regulation of synaptic genes contributes to the etiology of autism

Published:2021-05-04 Issue:7 Volume:32 Page:791-802
ISSN:0334-1763
Container-title:Reviews in the Neurosciences
language:en
Short-container-title:

Author:

Srancikova Annamaria¹,Bacova Zuzana¹,Bakos Jan¹²

Affiliation:

1. Institute of Experimental Endocrinology, Biomedical Research Center , Slovak Academy of Sciences , Dubravska cesta 9, 845 05 Bratislava , Slovakia

2. Institute of Physiology, Faculty of Medicine , Comenius University , Bratislava , Slovakia

Abstract

Abstract Epigenetic mechanisms greatly affect the developing brain, as well as the maturation of synapses with pervasive, long-lasting consequences on behavior in adults. Substantial evidence exists that implicates dysregulation of epigenetic mechanisms in the etiology of neurodevelopmental disorders. Therefore, this review explains the role of enzymes involved in DNA methylation and demethylation in neurodevelopment by emphasizing changes of synaptic genes and proteins. Epigenetic causes of sex-dependent differences in the brain are analyzed in conjunction with the pathophysiology of autism spectrum disorders. Special attention is devoted to the epigenetic regulation of the melanoma-associated antigen-like gene 2 (MAGEL2) found in Prader-Willi syndrome, which is known to be accompanied by autistic symptoms.

Publisher

Walter de Gruyter GmbH

Subject

General Neuroscience

Link

https://www.degruyter.com/document/doi/10.1515/revneuro-2021-0014/pdf

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