G protein-coupled receptor-receptor interactions give integrative dynamics to intercellular communication
Author:
Guidolin Diego1, Marcoli Manuela2, Tortorella Cinzia1, Maura Guido2, Agnati Luigi F.34
Affiliation:
1. Department of Neuroscience , University of Padova, via Gabelli 65 , I-35121 Padova , Italy 2. Department of Pharmacy and Center of Excellence for Biomedical Research , University of Genova , I-16126 Genova , Italy 3. Department of Biomedical Sciences , University of Modena and Reggio Emilia , I-41121 Modena , Italy 4. Department of Neuroscience , Karolinska Institutet , S-17177 Stockholm , Sweden
Abstract
Abstract
The proposal of receptor-receptor interactions (RRIs) in the early 1980s broadened the view on the role of G protein-coupled receptors (GPCR) in the dynamics of the intercellular communication. RRIs, indeed, allow GPCR to operate not only as monomers but also as receptor complexes, in which the integration of the incoming signals depends on the number, spatial arrangement, and order of activation of the protomers forming the complex. The main biochemical mechanisms controlling the functional interplay of GPCR in the receptor complexes are direct allosteric interactions between protomer domains. The formation of these macromolecular assemblies has several physiologic implications in terms of the modulation of the signaling pathways and interaction with other membrane proteins. It also impacts on the emerging field of connectomics, as it contributes to set and tune the synaptic strength. Furthermore, recent evidence suggests that the transfer of GPCR and GPCR complexes between cells via the exosome pathway could enable the target cells to recognize/decode transmitters and/or modulators for which they did not express the pertinent receptors. Thus, this process may also open the possibility of a new type of redeployment of neural circuits. The fundamental aspects of GPCR complex formation and function are the focus of the present review article.
Publisher
Walter de Gruyter GmbH
Subject
General Neuroscience
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