The emerging role of the chondroitin sulfate proteoglycan family in neurodegenerative diseases-Reference-Cited by-同舟云学术

The emerging role of the chondroitin sulfate proteoglycan family in neurodegenerative diseases

Published:2021-03-01 Issue:7 Volume:32 Page:737-750
ISSN:0334-1763
Container-title:Reviews in the Neurosciences
language:en
Short-container-title:

Author:

Lin Jia-zhe¹²,Duan Ming-rui²,Lin Nuan³,Zhao Wei-jiang²⁴

Affiliation:

1. Neurosurgical Department , The First Affiliated Hospital of Shantou University Medical College , Shantou 515041 , Guangdong , China

2. Center for Neuroscience , Shantou University Medical College , Shantou 515041 , Guangdong , China

3. Obstetrics and Gynecology Department , The First Affiliated Hospital of Shantou University Medical College , Shantou 515041 , Guangdong , China

4. Cell Biology Department , Wuxi School of Medicine, Jiangnan University , Wuxi 214122 , Jiangsu , China

Abstract

Abstract Chondroitin sulfate (CS) is a kind of linear polysaccharide that is covalently linked to proteins to form proteoglycans. Chondroitin sulfate proteoglycans (CSPGs) consist of a core protein, with one or more CS chains covalently attached. CSPGs are precisely regulated and they exert a variety of physiological functions by binding to adhesion molecules and growth factors. Widely distributed in the nervous system in human body, CSPGs contribute to the major component of extracellular matrix (ECM), where they play an important role in the development and maturation of the nervous system, as well as in the pathophysiological response to damage to the central nervous system (CNS). While there are more than 30 types of CSPGs, this review covers the roles of the most important ones, including versican, aggrecan, neurocan and NG2 in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis and multiple sclerosis. The updated reports of the treatment of neurodegenerative diseases are involving CSPGs.

Publisher

Walter de Gruyter GmbH

Subject

General Neuroscience

Link

https://www.degruyter.com/document/doi/10.1515/revneuro-2020-0146/pdf

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