Author:
Stabile Anna,Pistilli Alessandra,Crispoltoni Lucia,Montagnoli Claudia,Tiribuzi Roberto,Casali Lucio,Rende Mario
Abstract
Abstract
Nerve growth factor and its receptors, TrkA and p75NTR, are involved in inflammation and airways diseases, but their role in chronic obstructive pulmonary disease is still unclear and not well investigated. our data indicate the stage dependent variation of nerve growth factor and its receptors in chronic obstructive pulmonary disease progression. In fact, for the first time, this study evaluates the presence of nerve growth factor and its receptors in serum and in peripheral blood mononuclear cells of patients with different stages of chronic obstructive pulmonary disease compared to healthy subjects, non-smoker and current smoker. Serum monocyte chemoattractant protein-1, tumor necrosis factor-α, interleukin-10 and forced expiratory volume in 1 s were also analyzed. Compared to healthy subjects, chronic obstructive pulmonary disease patients presented a staging-dependent increase in serum nerve growth factor, negatively correlated to forced expiratory volume in 1 s and positively to monocyte chemoattractant Protein-1. The percentage of p75NTR+ peripheral blood mononuclear cells increased in early stages of chronic obstructive pulmonary disease (I–II), while TrKA+ peripheral blood mononuclear cells increased in late stages (III–IV). Our data demonstrate the involvement and modulation of nerve growth factor and its receptors in chronic obstructive pulmonary disease and in its staging.
Subject
Clinical Biochemistry,Molecular Biology,Biochemistry
Reference56 articles.
1. Nerve growth factor and its receptors in asthma and inflammation;Frossard;Eur J Pharmacol,2004
2. Nerve growth factor : a key local regulator in the pathogenesis of inflammatory arthritis;Raychaudhuri;Arthritis Rheum,2011
3. Nerve growth factor and its receptors in asthma and inflammation;Frossard;Eur J Pharmacol,2004
4. de Inflammatory and repair serum biomarker pattern Association to clinical outcomes in;Pinto;COPD Res,2012
5. Novel localization of low affinity NGF receptor in the stroma of prostate cancer and possible implication in neoplastic invasion : an immunohistochemical and ultracytochemical study;Rende;Prostate,2010
Cited by
12 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献