Author:
Clara Renan Orsati,Assmann Nadine,Ramos Moreno Ana Carolina,Coimbra Janine Baptista,Nurenberger Nadine,Dettmer-Wilde Katja,Oefner Peter Josef,Campa Ana
Abstract
Abstract
A key link between amino acid catabolism and immune regulation in cancer is the augmented tryptophan (Trp) catabolism through the kynurenine pathway (KP), a metabolic route induced by interferon-γ (IFN-γ) and related to poor prognosis in melanomas. Besides its role in cancer, IFN-γ plays a key role in the control of pigmentation homeostasis. Here we measured KP metabolites in human melanoma lines and skin melanocytes and fibroblasts in response to IFN-γ. In general, IFN-γ affected KP in skin cells more than in melanoma cells, supporting IFN-γ roles in skin physiology and that of stromal cells in modulating the tumor microenvironment.
Subject
Clinical Biochemistry,Molecular Biology,Biochemistry
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