Kinins and microglial responses in bipolar disorder: a neuroinflammation hypothesis

Author:

Naaldijk Yahaira M.,Bittencourt Maria C.,Sack Ulrich,Ulrich Henning

Abstract

Abstract Bipolar disorder (BD) is a severe psychiatric disorder that affects up to 15% of the worldwide population. Characterized by switches in mood between mania and depression, its etiology is still unknown and efforts have been made to elucidate the mechanisms involved in first episode, development and progression of the disorder. Microglia activation, abnormal activity of GSK-3β and reduction in neurotrophic factor expression related to neuroinflammatory processes have been indicated to be part of the disorder’s pathophysiology. Lithium, the main mood stabilizer used for the treatment and prevention of relapses, acts as an anti-inflammatory agent. Based on that, here we suggest a neuroinflammatory pathway for would be BD progression, in which microglia activation states modulated via constitutive induction of kinin-B1 receptor and reduction of kinin-B2 receptor expression and activity.

Publisher

Walter de Gruyter GmbH

Subject

Clinical Biochemistry,Molecular Biology,Biochemistry

Reference312 articles.

1. Berberine alleviates cardiac ischemia / reperfusion injury by inhibiting excessive autophagy in cardiomyocytes;Huang;Eur J Pharmacol

2. single nucleotide polymorphism in glycogen synthase kinase - beta promoter gene influences onset of illness in patients affected by bipolar disorder;Benedetti;Neurosci Lett,2004

3. Bradykinin - induced microglial migration mediated by bradykinin receptors depends on Ca influx via reverse - mode activity of the Na Ca exchanger;Ifuku;Neurosci,2007

4. receptor ligands therapeutic perspectives;Marceau;Nat Rev Drug Discov,2004

5. Neuroprotective role of bradykinin because of the attenuation of pro - inflammatory cytokine release from activated microglia;Noda;Neurochem,2007

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