Hypoxysordarin, a New Sordarin Derivative from Hypoxylon croceum

Abstract

Abstract Hypoxysordarin (1), a new sordarin derivative, was isolated from the fermentation broth of the facultative marine Hypoxylon croceum together with a new y-lactone, hypoxylactone (2) and sordarin (3). The structures were determined by spectroscopic m ethods. Sordarin (3) has previously been isolated from the terrestrial Sordaria araneosa (Sordariaceae). Like the parent com pound hypoxysordarin exhibits high antifungal activities due to a specific inhibition of protein biosynthesis