Noroudemansin A, a New Antifungal Antibiotic from Pterula Species 82168 and Three Semisynthetic Derivatives

Author:

Engler-Lohr Michaela1,Anke Timm1,Hellwig Veronika2,Steglich Wolfgang2

Affiliation:

1. Lehrbereich Biotechnologie der Universität. Paul-Ehrlich-Str. 23, D-67663 Kaiserslautern, Germany

2. Institut für Organische Chemie der Universität München, Karlstraße 23, D-80333 München,Germany

Abstract

A new antifungal (E)-β-methoxyacrylate, noroudemansin A (1), was isolated from cultures of Pterula sp. 82168. Its biological activities were investigated and compared with oudemansin A. The structure was elucidated by spectroscopic methods. Three semisynthetic noroudemansin A derivatives were synthesized from the natural product.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

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