Engineering of biodegradable magnesium alloy scaffolds to stabilize biological myocardial grafts

Abstract

AbstractObjective:Regenerative bioprostheses are being investigated for replacement of dysfunctional myocardium worldwide. The aim of this study was to develop a degradable magnesium structure to mechanically support the delicate biological grafts during the early remodeling phase.Methods:Sheets of magnesium alloys (LA33, LA63 and AX30) were manufactured into scaffolds by abrasive water jet cutting. Thereafter, their surface properties, corrosion kinetics, and breakage behaviors were investigated.Results:The magnesium alloy LA63 sheets proved superior to the other alloys in terms of load cycles (lc) until break of the specimens (LA63: >10 Mio lc; AX30: 676,044±220,016 lc; LA33: 423,558±210,063 lc; p<0.01). Coating with MgF led to better protection than coating with MagPass. Less complex, yet sufficiently flexible scaffolds were less prone to early breakage. A slow traverse rate during water jet cutting resulted in the lowest burr, but in a widening of the kerf width from 615±11 μm at 500 mm/min to 708±33 μm at 10 mm/min (p<0.01).Conclusion:The findings on alloy composition, coating, structural geometry and manufacturing parameters constitute a basis for clinically applicable magnesium scaffolds. The use of stabilized, regenerative myocardium prostheses could save the patients from severe morbidity and eventually death.