Effect of alkan-1-ols on the structure of dopc model membrane-Reference-Cited by-同舟云学术

Effect of alkan-1-ols on the structure of dopc model membrane

Published:2017-11-27 Issue:2 Volume:64 Page:4-8
ISSN:2453-6725
Container-title:European Pharmaceutical Journal
language:en
Short-container-title:

Author:

Kondela T.¹,Gallová J.²,Hauß T.³,Ivankov O.⁴⁵⁶,Kučerka N.¹⁴,Balgavý P.²

Affiliation:

1. Comenius University in Bratislava, Faculty of Pharmacy, Department of Physical Chemistry, Bratislava , Slovak Republic

2. Comenius University in Bratislava, Faculty of Pharmacy, Department of Physical Chemistry, Bratislava , Slovakia

3. Helmholtz Zentrum Berlin für Materialen und Energie, Berlin , Germany

4. Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, Dubna , Russian Federation

5. Moscow Institute of Physics and Technology, MIPT, Dolgoprudny , Russian Federation

6. Institute for Safety Problems of Nuclear Power Plants, NAS Ukraine, Kiev , Ukraine

Abstract

Abstract The effect of general anaesthetics alkan-1-ols (CnOH, where n = 10, 12, 14, 16 and 18 is the number of carbon atoms in the molecule) on the structure of dioleoylphosphatidylcholine (DOPC) model membrane was studied by small-angle neutron scattering (SANS) and small-angle neutron diffraction (SAND). Fluid bilayers were prepared at CnOH:DOPC = 0.3 molar ratio. The results of both the experiments show that bilayer thickness - a thickness parameter dg in the case of SANS and lamellar repeat distance D in the case of SAND - increases with increasing n. A coexistence of two lamellar phases with different D was detected by measuring the C18OH+DOPC oriented sample.

Publisher

Walter de Gruyter GmbH

Subject

General Pharmacology, Toxicology and Pharmaceutics

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