Affiliation:
1. Slovenská akadémia vied, Biomedicínske centrum SAV, Bratislava , Slovakia
2. Univerzita sv. Cyrila a Metoda v Trnave, Fakulta prírodných vied, Trnava , Slovakia
Abstract
Abstract
Family of T-type or low-voltage activated calcium channels consists of three members: CaV3.1, CaV3.2, and CaV3.3. CaV3.2 channel has almost identical biophysical properties as the CaV3.1 channel, but is distinguished by a specific tissue expression profile and a prominent role in several pathologies, including neuropathic pain, epilepsy, and dysregulation of cardiac rhythm. Further, it may be involved in phenotype of autism spectrum disorders, and amyotrophic lateral sclerosis. It represents a promising target for future pharmacotherapies.
Subject
General Pharmacology, Toxicology and Pharmaceutics
Reference68 articles.
1. [1] Agler HL, Evans J, Tay LH, Anderson MJ, Colecraft HM, Yue DT. G protein-gated inhibitory module of N-type (Cav2.2) Ca2+ channels. Neuron. 2005; 46:891-904.
2. [2] Aguado C, Garcia-Madrona S, Gil-Minguez M, Lujan R. Ontogenic Changes and Differential Localization of T-type Ca(2+) Channel Subunits Cav3.1 and Cav3.2 in Mouse Hippocampus and Cerebellum. Front Neuroanat. 2016; 10:83.
3. [3] Ayoola C, Hwang SM, Hong SJ, Rose KE, Boyd C, Bozic N, Park JY, Osuru HP, DiGruccio MR, Covey DF, Jevtovic-Todorovic V, Todorovic SM. Inhibition of CaV3.2 T-type calcium channels in peripheral sensory neurons contributes to analgesic properties of epipregnanolone. Psychopharmacology (Berl). 2014; 231:3503-15.
4. [4] Barbara G, Alloui A, Nargeot J, Lory P, Eschalier A, Bourinet E, Chemin J. T-type calcium channel inhibition underlies the analgesic effects of the endogenous lipoamino acids. J Neurosci. 2009; 29:13106-14.
5. [5] Berthier C, Monteil A, Lory P, Strube C. Alpha(1H) mRNA in single skeletal muscle fibres accounts for T-type calcium current transient expression during fetal development in mice. J Physiol. 2002; 539:681-91.