Analytic solution of a fractional-order hepatitis model using Laplace Adomian decomposition method and optimal control analysis

Author:

Aguegboh Nnaemeka S.1,Roy Kiogora Phineas2,Felix Mutua3,Okongo Walter1,Diallo Boubacar1

Affiliation:

1. Department of Mathematics, Pan African University Institute for Basic Sciences, Technology and Innovation , JKUAT , P.O. Box 62000 – 00200, Nairobi , Kenya

2. Department of Mathematics, Jomo Kenyetta University of Agriculture and Technology , P.O. Box 62000 – 00200 , Nairobi , Kenya

3. Department of Mathematics, Statistics and Physical Sciences, Taita Taveta University , P.O. Box 635 – 80300 , Voi , Kenya

Abstract

Abstract Infectious illnesses like hepatitis place a heavy cost on global health, and precise mathematical models must be created in order to understand and manage them. The Adomian decomposition method (ADM) and an optimal control strategy are utilized to solve a fractional-order hepatitis model in this research. By adding fractional derivatives to account for memory effects and non-integer order dynamics, the fractional-order model expands the conventional compartmental model to take into account the complexity of hepatitis dynamics. The fractional-order hepatitis model is resolved using the ADM, a powerful and effective analytical approach. This approach offers a series solution that converges quickly, enabling the model’s precise analytical solution to be derived. To identify crucial criteria and enhance control mechanisms for the management of hepatitis, an optimal solution strategy is also introduced. The optimization procedure tries to lessen the disease’s spread and its negative effects on public health. We can find the best interventions, immunization schedules, and treatment regimens to effectively reduce the hepatitis pandemic by integrating the ADM solution with an optimization framework. The findings of this study show that the suggested method may be used to solve the fractional-order hepatitis model and optimize control measures. The analytical solution produced by ADM offers important insights into the underlying dynamics of hepatitis transmission, and the optimization process produces suggestions that public health professionals and politicians may put into practice. In the end, this research presents a promising direction for improving disease control efforts in a fractional-order context and contributes to a deeper understanding of hepatitis epidemiology. The importance of this method is that it gives solutions that coincide with that obtained using the numerical approach.

Publisher

Walter de Gruyter GmbH

Reference15 articles.

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3. Eric Okyere, F. T. (2016). Fractional order SIR model with constant population. British Journal of Mathematics and Computer Science, 14(2), 1–12.

4. Nnaemeka, A. A., & Amanso, O. R. (2021). Analysis of a model on the transmission dynamics (with prevention and control) of Hepatitis B. Journal of Fractional Calculus and Applications, 12(1), 76–89.

5. Medicins Sans Frontiers- Middle East. (2016). Retrieved May 9, 2018, from https://www.msf-me.org/issues/hepatitis.

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