A highly efficient and green approach for the synthesis of pyrimido[4,5-b]quinolines using N,N-diethyl-N-sulfoethanaminium chloride
Author:
Zare Abdolkarim1, Dianat Manije1
Affiliation:
1. Department of Chemistry , Payame Noor University , P. O. Box 19395‐3697 , Tehran , I. R. Iran
Abstract
Abstract
A highly efficient and green protocol for the synthesis of pyrimido[4,5-b]quinolines has been described. The one-pot multicomponent reaction of dimedone with arylaldehydes and 6-amino-1,3-dimethyluracil in the presence of N,N-diethyl-N-sulfoethanaminium chloride ([Et3N–SO3H][Cl]) as an ionic liquid (IL) catalyst under solvent-free conditions afforded the mentioned compounds in high yields and short reaction times. Our protocol is superior to many of the reported protocols in terms of two or more of these factors: the reaction times, yields, conditions (solvent-free versus usage of organic solvents), temperature and catalyst amount.
Funder
Research Council of Payame Noor University
Publisher
Walter de Gruyter GmbH
Subject
General Chemistry
Reference44 articles.
1. Nargund, L. V. G., Badiger, V. V., Yarnal, S. M. J. Pharm. Sci. 1992, 81, 365; https://doi.org/10.1002/jps.2600810416. 2. Nair, V., Chi, G., Shu, Q., Julander, J., Smee, D. F. Bioorg. Med. Chem. Lett. 2009, 19, 1425; https://doi.org/10.1016/j.bmcl.2009.01.031. 3. Kostova, I., Atanasov, P. Y. Curr. Org. Chem. 2017, 21, 2096; https://doi.org/10.2174/1385272820666161025152154. 4. Kim, S.-M., Lee, M., Lee, S. Y., Lee, S.-M., Kim, E. J., Kim, J. S. Ann, J., Lee, J., Lee, J. Eur. J. Med. Chem. 2018, 145, 413; https://doi.org/10.1016/j.ejmech.2017.12.095. 5. Xia, Y., Yang, Z. Y., Xia, P., Bastow, K. F., Tachibana, Y., Kuo, S. C., Hamel, E., Hackl, T., Lee, K. H. J. Med. Chem. 1998, 41, 1155; https://doi.org/10.1021/jm9707479.
Cited by
8 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
|
|