The reaction of imidazo[1,5-a]pyridines with ninhydrin revisited-Reference-Cited by-同舟云学术

The reaction of imidazo[1,5-a]pyridines with ninhydrin revisited

Published:2020-06-29 Issue:6-7 Volume:75 Page:559-565
ISSN:1865-7117
Container-title:Zeitschrift für Naturforschung B
language:en
Short-container-title:

Author:

El-Abadelah Mustafa M.¹,Awwadi Firas F.¹,Abdullah Ahmad H.¹,Voelter Wolfgang²

Affiliation:

1. Department of Chemistry, Faculty of Science , The University of Jordan , Amman , 11942 , Jordan

2. Interfakultäres Institut für Biochemie , Universität Tübingen , Hoppe-Seyler Straße 4 , Tübingen , 72076 , Germany

Abstract

Abstract The synthesis of 2,2′-(Imidazo[1,5-a]pyridine-1,3-diyl)bis(2-hydroxy-1H-indene-1,3(2H)-dione) (11) is achieved by reaction of imidazo[1,5-a]pyridine (7) with two equivalents of ninhydrin (1) at room temperature. The structure of this new 1,3-bis-adduct 11 is evidenced from HRMS and NMR spectral data and confirmed by single-crystal X-ray crystallography. Employment of equimolar amounts of 1 and 7 gave a separable mixture of the respective 1- and 3-monomeric adducts (9, 10).

Funder

Deanship of Scientific Research at The University of Jordan

Publisher

Walter de Gruyter GmbH

Subject

General Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/znb-2020-0027/pdf

Reference13 articles.

1. Bower, J. D., Ramage, G. R., J. Chem. Soc. 1955, 2834.

2. Hlasta, D. J., Silbernagel, J., Heterocycles 1998, 48, 1015.

3. Paudler, W. W., Kuder, J. E., J. Org. Chem. 1967, 32, 2430.

4. Fuentes, O., Paudler, W. W., J. Herocycl. Chem. 1975, 12, 379.

5. Paudler, W. W., Chao, C. I. P., Helmick, L. S., J. Heterocycl. Chem. 1972, 9, 1157.

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Design, synthesis and biological evaluation of novel 2-hydroxy-1 H-indene-1,3(2 H)-dione derivatives as FGFR1 inhibitors;Pharmacia;2024-04-23

2. New Applications of Ninhydrin in the Synthesis of Polyheterocyclic Compounds;Russian Journal of Organic Chemistry;2023-01