Author:
Simhadri Vijaya Lakshmi,Hansen Hinrich P.,Simhadri Venkateswara R.,Reiners Katrin S.,Bessler Martina,Engert Andreas,von Strandmann Elke Pogge
Abstract
Abstract
The interplay between dendritic cells (DCs) and natural killer (NK) cells directs adaptive immune responses. The molecular basis of the cross-talk is largely undefined. Here, we provide evidence for a contribution of CD30 (TNFRSF8) and its ligand CD30L (TNFSF8) expressed on NK cells and DCs, respectively. We demonstrate that CD30-mediated engagement of CD30L induced cytokine secretion from immature DCs via the mitogen-activated protein kinase pathway. Moreover, CD30L engagement promoted differentiation to mature DCs. On the contrary, the engagement of CD30 on NK cells resulted in an NF-κB-dependent release of TNF-α/IFN-γ. These data uncover a novel and unexpected role for CD30/CD30L that contributes to proinflammatory immune responses.
Subject
Clinical Biochemistry,Molecular Biology,Biochemistry
Cited by
14 articles.
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