Anti-inflammatory effect and isolation of phenylethanoid and acylated flavone glycosides from Panzeria alaschanica

Abstract

Abstract The phytochemical study of the EtOAc extract from Panzeria alaschanica resulted in the isolation of two new acylated flavone glycosides, 5,7,4′-trihydroxyflavone-7-O-(6″-O-[E]-coumaroyl)-β-glucopyranoside (1) and 5,7,4′-trihydroxyflavone-7-O-(2″,6″-O-[E]-dicoumaroyl)-β-glucopyranoside (2), as well as of a known phenylethanoid (verbascoside, 3). The structure of the isolated compounds was elucidated by spectroscopic methods, including ultraviolet spectrophotometry, infrared absorption spectroscopy, electrospray ionization mass spectrometry and 1D nuclear magnetic resonance spectroscopy, and by comparison with those reported in the literature. All compounds were investigated for their effect against inflammation induced by egg albumin and carrageenan in rats.