Synthesis and antitubercular activity of new N-[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]-(nitroheteroaryl)carboxamides-Reference-Cited by-同舟云学术

Synthesis and antitubercular activity of new N-[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]-(nitroheteroaryl)carboxamides

Published:2019-04-19 Issue:1 Volume:25 Page:52-59
ISSN:2191-0197
Container-title:Heterocyclic Communications
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Author:

Martínez Roberto¹,Zamudio Gladys J. Nieves¹,Pretelin-Castillo Gustavo¹,Torres-Ochoa Rubén O.¹,Medina-Franco José L.²,Espitia Pinzón Clara I.³,Miranda Mayra Silva⁴,Hernández Eugenio⁵,Alanís-Garza Blanca⁶

Affiliation:

1. Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, 04510, Cd. México, México

2. Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, Avenida Universidad3000, 04510Cd. México, México

3. Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, 04510, Cd. México, México

4. Catedrática CONACYT adscrita al Insituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, 04510, Cd. México, México

5. Facultad de Ciencias Químicas, Universidad Autónoma de Nuevo León, Pedro de Alba s/n, Ciudad Universitaria, 66400 San Nicolás de los Garza, Nuevo León, México

6. Departamento de Química Analítica, Facultad de Medicina, Universidad Autónoma de Nuevo León, Madero s/n Col. Mitras Centro. Monterrey, N. L. MéxicoC. P. 64460

Abstract

AbstractNitro-substituted heteroaromatic carboxamides 1a-e were synthesized and tested against three Mycobacterium tuberculosis cell lines. The activities can be explained in terms of the distribution of the electronic density across the nitro-substituted heteroaromatic ring attached to the amide group. 1,3,5-Oxadiazole derivatives 1c-e are candidates for the development of novel antitubercular agents. Ongoing studies are focused on exploring the mechanism by which these compounds inhibit M. tuberculosis cell growth.

Publisher

Walter de Gruyter GmbH

Subject

Organic Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/hc-2019-0007/pdf

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