Substrate-controlled Diastereoselective Michael Addition of Alkylidene Malonates by Grignard Reagents-Reference-Cited by-同舟云学术

Substrate-controlled Diastereoselective Michael Addition of Alkylidene Malonates by Grignard Reagents

Published:2019-11-28 Issue:1 Volume:25 Page:116-121
ISSN:2191-0197
Container-title:Heterocyclic Communications
language:
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Author:

Zhou Wei¹,Xiao Qingwei¹,Chang Yuanyuan¹,Liu Qifa¹,Zang Xiaohao¹,Hu Mengmeng¹,Zeng Xi¹,Du Zhiyun¹,Zhong Guifa²

Affiliation:

1. School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, 100 Waihuanxi Road, Guangzhou Higher Education Mega Center, Guangzhou510006, PR China

2. Drug Discovery Pipeline, Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Science Park, Guangzhou510530, PR China

Abstract

AbstractHerein is described a diastereoselective Michael addition of Grignard reagents to α, β- unsaturated diethyl malonates incorporated with a 2-oxazolidone chiral auxiliary. The catalyst-free Michael addition proceeds with good chemical efficiency and excellent stereoselectivity; and it provides new thoughts to the asymmetric synthesis of β-substituted β3 amino acid derivatives.

Publisher

Walter de Gruyter GmbH

Subject

Organic Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/hc-2019-0019/pdf

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