Human stem cell modeling of neuropsychiatric disorders: from polygenicity to convergence
Author:
Affiliation:
1. Center for Psychiatric Genetics, NorthShore University Health System Research Institute , Evanston , IL , USA
2. Department of Psychiatry and Behavioral Neuroscience , The University of Chicago , Chicago , IL , USA
Abstract
Funder
NIH
Publisher
Walter de Gruyter GmbH
Link
https://www.degruyter.com/document/doi/10.1515/mr-2023-0016/pdf
Reference13 articles.
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2. Snyder, SH. The dopamine hypothesis of schizophrenia: focus on the dopamine receptor. Am J Psychiatr 1976;133:197–202. https://doi.org/10.1176/ajp.133.2.197.
3. Trubetskoy, V, Pardiñas, AF, Qi, T, Panagiotaropoulou, G, Awasthi, S, Bigdeli, TB, et al.. Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature 2022;604:502–8. https://doi.org/10.1038/s41586-022-04434-5.
4. Singh, T, Poterba, T, Curtis, D, Akil, H, Al Eissa, M, Barchas, JD, et al.. Rare coding variants in ten genes confer substantial risk for schizophrenia. Nature 2022;604:509–16. https://doi.org/10.1038/s41586-022-04556-w.
5. Takahashi, K, Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006;126:663–76. https://doi.org/10.1016/j.cell.2006.07.024.
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