The role of Down syndrome cell adhesion molecule in Down syndrome
Author:
Hergenreder Ty1, Yang Tao1, Ye Bing1ORCID
Affiliation:
1. Life Sciences Institute and Department of Cell and Developmental Biology , University of Michigan , Ann Arbor , MI , USA
Abstract
Abstract
Down syndrome (DS) is caused by the presence of an extra copy of the entire or a portion of human chromosome 21 (HSA21). This genomic alteration leads to elevated expression of numerous HSA21 genes, resulting in a variety of health issues in individuals with DS. Among the genes located in the DS “critical region” of HSA21, Down syndrome cell adhesion molecule (DSCAM) plays an important role in neuronal development. There is a growing body of evidence underscoring DSCAM’s involvement in various DS-related disorders. This review aims to provide a concise overview of the established functions of DSCAM, with a particular focus on its implications in DS. We delve into the roles that DSCAM plays in DS-associated diseases. In the concluding section of this review, we explore prospective avenues for future research to further unravel DSCAM’s role in DS and opportunities for therapeutic treatments.
Funder
Down syndrome research in the Ye lab was supported by funding from National Institutes of Health Brain Research Foundation, and the Protein Folding Disease Initiative of the University of Michigan
Publisher
Walter de Gruyter GmbH
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