Growth Inhibitions on Human Cancer Cell Cultures with the Indole Sulphur-Containing Phytoalexins and Their Analogues

Abstract

Abstract Cell growth inhibitions on human cancer cell cultures were determined for the indole sulphur-containing phytoalexins cyclobrassinin, brassilexin (previously isolated from vegetables of the Cruciferae family) and their synthetic analogues 5-methoxybrassilexin and homocyclobrassinin. The most biologically active of these products is brassilexin (LD50= 8 μg/ml).