Tumor visualization and fluorescence angiography with indocyanine green (ICG) in laparoscopic and robotic hepatobiliary surgery – valuation of early adopters from Germany
Author:
Franz Mareike1, Arend Jörg1, Wolff Stefanie1, Perrakis Aristotelis1, Rahimli Mirhasan1, Negrini Victor-Radu1, Stockheim Jessica1, Lorenz Eric1, Croner Roland1
Affiliation:
1. Department of General-, Visceral-, Vascular-, and Transplant-Surgery , University Hospital Magdeburg , Magdeburg , Germany
Abstract
Abstract
Objectives
Indocyanine green (ICG) is a fluorescent dye which was initially used for liver functional assessment. Moreover, it is of value for intraoperative visualization of liver segments and bile ducts or primary and secondary liver tumors. Especially in minimally invasive liver surgery, this is essential to enhance the precision of anatomical guided surgery and oncological quality. As early adopters of ICG implementation into laparoscopic and robotic-assisted liver surgery in Germany, we summarize the current recommendations and share our experiences.
Methods
Actual strategies for ICG application in minimally invasive liver surgery were evaluated and summarized during a review of the literature. Experiences in patients who underwent laparoscopic or robotic-assisted liver surgery with intraoperative ICG staining between 2018 and 2020 from the Magdeburg registry for minimally invasive liver surgery (MD-MILS) were evaluated and the data were analyzed retrospectively.
Results
ICG can be used to identify anatomical liver segments by fluorescence angiography via direct or indirect tissue staining. Fluorescence cholangiography visualizes the intra- and extrahepatic bile ducts. Primary and secondary liver tumors can be identified with a sensitivity of 69–100%. For this 0.5 mg/kg body weight ICG must be applicated intravenously 2–14 days prior to surgery. Within the MD-MILS we identified 18 patients which received ICG for intraoperative tumor staining of hepatocellular carcinoma (HCC), cholangiocarcinoma, peritoneal HCC metastases, adenoma, or colorectal liver metastases. The sensitivity for tumor staining was 100%. In 27.8% additional liver tumors were identified by ICG fluorescence. In 39% a false positive signal could be detected. This occurred mainly in cirrhotic livers.
Conclusions
ICG staining is a simple and useful tool to assess individual hepatic anatomy or to detect tumors during minimally invasive liver surgery. It may enhance surgical precision and improve oncological quality. False-positive detection rates of liver tumors can be reduced by respecting the tumor entity and liver functional impairments.
Publisher
Walter de Gruyter GmbH
Reference51 articles.
1. Huang, S-W, Ou, J-J, Wong, HP. The use of indocyanine green imaging technique in patient with hepatocellular carcinoma. Transl Gastroenterol Hepatol. 2018;3. https://doi.org/10.21037/tgh.2018.10.15. 2. Guyer, DR, Puliafito, CA, Monés, JM, Friedman, E, Chang, W, Verdooner, SR. Digital indocyanine-green angiography in chorioretinal disorders. Ophthalmology 1992;99:287–91. https://doi.org/10.1016/s0161-6420(92)31981-5. 3. Cherrick, GR, Stein, SW, Leevy, CM, Davidson, CS. Indocyanine green: observations on its physical properties, plasma decay, and hepatic extraction. J Clin Invest 1960;39:592–600. https://doi.org/10.1172/jci104072. 4. de Graaf, W, Häusler, S, Heger, M, van Ginhoven, TM, van Cappellen, G, Bennink, RJ, et al.. Transporters involved in the hepatic uptake of (99m)Tc-mebrofenin and indocyanine green. J Hepatol 2011;54:738–45. https://doi.org/10.1016/j.jhep.2010.07.047. 5. Baker, KJ. Binding of sulfobromophthalein (BSP) sodium and indocyanine green (ICG) by plasma alpha-1 lipoproteins. Proc Soc Exp Biol Med 1966;122:957–63. https://doi.org/10.3181/00379727-122-31299.
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