Green protocols for Tsuji–Trost allylation: an overview

Abstract

Abstract Since its inception in 1960s, the Tsuji–Trost reaction, an allylic substitution reaction with diverse nucleophiles such as phenols, amines, thiols, and active methylene compounds, has remained as one of the most useful and widely used organic reactions for the construction of C–C and C–heteroatom bonds. Allylic compounds such as allylic acetates, alcohols, halides, and carbonates undergo this transformation which plays an important role in the total synthesis of various natural products. The competence to incorporate synthetically demanding allylic functionalities makes it a beneficial tool for the synthesis of complex molecules. Over the last two decades, major advancements for this unique and facile Tsuji–Trost allylation reaction have been made with special emphasis to develop greener and sustainable protocols. This chapter presents an update on the significant progress focusing on the newly designed catalytic systems with high efficiency, the use of eco-friendly solvents or solvent-free conditions, low or room temperature conditions and waste management, along with future outlook.