Synthesis and antifungal activities of 3-substituted phthalide derivatives-Reference-Cited by-同舟云学术

Synthesis and antifungal activities of 3-substituted phthalide derivatives

Published:2019-10-14 Issue:11-12 Volume:74 Page:811-818
ISSN:1865-7117
Container-title:Zeitschrift für Naturforschung B
language:en
Short-container-title:

Author:

Fan Lingling¹,Luo Bilan¹,Luo Zhongfu¹,Zhang Li¹,Fan Judi¹,Xue Wei²,Tang Lei³,Li Yong³

Affiliation:

1. College of Pharmacy, State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R & D , Guizhou Medical University , Guiyang 550004 , P.R. China

2. Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education , Guizhou University , Guiyang 550025 , P.R. China

3. College of Pharmacy, State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Provincial Engineering Technology Research Center for Chemical Drug R & D , Guizhou Medical University , Guiyang 550004 , P.R. China , Tel./Fax: +86-0851-86908318

Abstract

Abstract In order to obtain novel bioactive compounds with significant antifungal activities, two series of 3-substituted phthalide derivatives were designed and synthesized via reduction, bromine substitution, and etherification. In addition, the antifungal activities of all target compounds against nine phytopathogenic fungi in vitro were tested by using the mycelial growth rate method at the concentration of 50 μg mL−1. Preliminary bioassay tests showed that some compounds exhibited more potent antifungal activities as compared with hymexazol. The preliminary structure-activity relationships (SARs) of all target compounds were also investigated.

Publisher

Walter de Gruyter GmbH

Subject

General Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/znb-2019-0110/pdf

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