Author:
Šeruga Maja,Kariž Stojan,Makuc Jana,Završnik Matej,Cilenšek Ines,Gazdikova Katarina,Caprnda Martin,Kruzliak Peter,Petrovič Daniel
Abstract
AbstractBackground:Diabetic nephropathy (DN) is a major microvascular complication of type 2 diabetes mellitus (T2DM). Several lines of evidence implicate the endothelin (ET) system in the pathophysiology of DN. The aim of the present study was to analyze if genetic polymorphisms of the ET-1 (EDN1) gene affect susceptibility to DN in Caucasians with T2DM.Materials and methods:The study population consisted of 651 Caucasian subjects with T2DM of more than 10 years’ duration: 276 patients with DN (cases) and 375 patients without evidence of DN (controls). Polymorphisms in ET-1 (EDN1) gene, rs5370, rs1476046, and rs3087459, were studied.Results:Genotype distributions of the studied polymorphisms showed no significant difference between cases and controls.Conclusions:We provide evidence that the rs5370, rs1476046, and rs3087459 polymorphisms ofEDN1gene are not risk factors for DN in Caucasians with T2DM.
Reference45 articles.
1. Association of single nucleotide polymorphisms in endothelin family genes with the progression of atherosclerosis in patients with essential hypertension;Yasuda;J Hum Hypertens,2007
2. CD Characterization of endothelins as chemoattractants for human neutrophils;Wright;Life Sci,1994
3. receptor blockade reduces diabetic renal injury via an anti - inflammatory mechanism;Sasser;Endothelin J Am Soc Nephrol,2007
4. Regulation of blood pressure and salt homeostasis by endothelin;Kohan;Physiol Rev,2011
5. enhances neutrophil adhesion to human coronary artery endothelial cells : role of ET receptors and platelet - activating factor;Zouki;Endothelin Pharmacol,1999
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