Evaluation of Silymarin as a Promising Radioprotector

Author:

Adhikari Manish1,Arora Rajesh12,Chawla Raman1,Sharma Jyoti1,Dhaker Atlar Singh1,Gupta Damodar1,Dubey Neha1,Kumar Raj1,Ivanov Veselin2,Gevrenova Renata3,Sharma Rakesh Kumar1

Affiliation:

1. Institute of Nuclear Medicine and Allied Sciences, Brig SK Mazumdar Marg, Delhi-110054, India

2. Department of Chemistry and Biochemistry, Medical Faculty, Trakia University, Armeiska 11, Stara Zagora 6000, Bulgaria

3. Faculty of Pharmacy, Medical University Sofia, Dunav Str. 2, Sofi a 1000, Bulgaria

Abstract

Silymarin, a purified extract of seeds of Silybum marianum L. and well known for its hepatoprotective abilities, has been evaluated for inherent utility as a radioprotective agent. A fraction (INM-7035) was authenticated by characterizing the percentage composition of silybin A and B (39.9% and 57.4%). Free radical scavenging activities of INM-7035 against superoxide radicals (>68%), hydroxyl radicals (>33.75%), DPPH (67.2%), and ABTS (32.4%) were also evaluated. The fraction chelated (>30%) ferrous ions, thereby able to restrict amplification. INM-7035 exhibited >50% peroxyl radical scavenging activity in the lipid phase along with dose-dependent (R2 = 0.990) reducing power in the aqueous phase. Radiation-induced free radical flux can lead to disruption of biomolecules like membrane lipids. INM-7035 completely inhibited lipid peroxidative stress in case of membranes against supralethal radiation stress in the liposomal system. The ability of INM-7035 to modulate the levels of NF-κB, indicated its inherent potential as a radioprotective bioactive constituent.

Publisher

Walter de Gruyter GmbH

Subject

General Biochemistry, Genetics and Molecular Biology

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