Pharmacokinetics of Doxycycline in Ducks with Steatosis due to Force-feeding
Author:
Bratoev Neno1, Milanova Aneliya1, Pavlova Ivelina1, Lashev Lubomir1
Affiliation:
1. Department of Pharmacology, Physiology and Physiological Chemistry, Faculty of Veterinary Medicine , Trakia University , Bulgaria
Abstract
Abstract
The pharmacokinetics of doxycycline was investigated in force-fed and normally fed ducks after single intravenous (i.v.) and oral (p.o.) administration at a dose of 15 mg/kg bw. Serum concentrations of the drug were determined by the HPLC method. Pharmacokinetic parameters were calculated using compartmental analysis. Serum concentrations of doxycycline after i.v. administration in both groups were not statistically different. The values of half-lives were 5.82±1.85 h and 6.06±5.51 h in normal and force-fed birds. The total body clearance was respectively 0.40±0.05 L/h/kg and 0.34±0.10 L/h/kg, and volume of distribution (Vss) was 2.80±0.85 L/kg and 2.18±0.89 L/kg. After p.o. administraton the maximum serum levels in the control group were 0.70±0.12 μg/mL and in force-fed birds were 1.93±0.32 μg/mL, measured at 2.95±0.60 h and 1.45±0.24 h, respectively. The values of absolute bioavailability were 18.89±6.48% and 37.58±13.63%. Longer doxycycline retention in force-fed ducks was registered. Our data can be accepted as an information for possible prolonged retention of doxycycline in force fed ducks compared to normally fed ones.
Publisher
Walter de Gruyter GmbH
Subject
General Veterinary
Reference20 articles.
1. 1. Pijpers, A., Van Klingeren, B., Schoevers, E.J., Verheijden, J.H.M., Van Miert, A.S. (1989). In vitro activity of five tetracyclines and some other antimicrobial agents four porcine respiratory tract pathogens. J. Vet. Pharmacol. Ther. 12, 267–276. http://dx.doi.org/10.1111/j.1365-2885.1989.tb00670.x PMid:2810475 2. 2. Anadón, A., Martínez-Larra-aga, M.R., Diaz, M.J., Bringas, P., Fernandez, M.C., Fernandez-Cruz, M.L., Iturbe, J., Martínez, M.A. (1994). Pharmacokinetics of doxycycline in broiler chickens. Avian Pathol. 23, 79-90. http://dx.doi.org/10.1080/03079459408418976 PMid:18671073 3. 3. Poapolathep, A., Poapolathep, S., Imsilp, K., Noonpugdee, C., Klangkaew, N., Kusujarit, N., Tirawattanawanich, C., Subsinsoonthon, B. (2005). Pharmacokinetics and bioavailability of doxycycline in Thai native chickens. J. Thai. Vet. Med. Assoc. 56, 59–65. 4. 4. Yang, F., Li, GH., Meng, X.B., Wang, L.Q., Huang, X.H., Shan, Q., Zeng, D.P., Ding, H.Z., Zeng, Z.L. (2012). Pharmacokinetic interactions of flunixin meglumine and doxycycline in broiler chickens. J. Vet. Pharmacol. Ther. 36, 85–88. http://dx.doi.org/10.1111/j.1365-2885.2012.01382.x PMid:22292913 5. 5. Küng, K., Wanner, M. (1994). Pharmacokinetics of Doxycycline in turkeys and comparison between feed and water medication. Archiv für Geflügelkunde 58, 84–88.
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