Targeting autophagy for the treatment of cancer
Affiliation:
1. Institute for Experimental Cancer Research in Pediatrics, Goethe-University Frankfurt , Komturstr. 3a , D-60528 Frankfurt , Germany 2. German Cancer Consortium (DKTK) , Partner Site Frankfurt , 60590 Frankfurt , Germany 3. German Cancer Research Center (DKFZ) , 69120 Heidelberg , Germany
Abstract
Abstract
Macroautophagy (herein termed autophagy) is evolutionarily highly conserved across eukaryotic cells and represents an intracellular catabolic process that targets damaged macromolecules and organelles for degradation. Autophagy is dysregulated in various human diseases including cancer. In addition, many drugs currently used for the treatment of cancer can engage autophagy, which typically promotes cancer cell survival by mitigating cellular stress. However, under certain circumstances activation of autophagy upon anticancer drug treatment can also trigger a lethal type of autophagy termed autophagic cell death (ACD). This may pave new avenues for exploiting the autophagic circuitry in oncology. This review presents the concept and some examples of anticancer drug-induced ACD.
Publisher
Walter de Gruyter GmbH
Subject
Clinical Biochemistry,Molecular Biology,Biochemistry
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