Involvement of mitophagy in cisplatin-induced cell death regulation
Author:
Abdrakhmanov Alibek1, Kulikov Andrey V.1, Luchkina Ekaterina A.1, Zhivotovsky Boris12, Gogvadze Vladimir12
Affiliation:
1. MV Lomonosov Moscow State University , 119991 Moscow , Russia 2. Institute of Environmental Medicine, Division of Toxicology, Karolinska Institutet , Box 210, SE-171 77 Stockholm , Sweden
Abstract
Abstract
Mitophagy, the selective degradation of mitochondria via the autophagic pathway, is a vital mechanism of mitochondrial quality control in cells. The removal of malfunctioning or damaged mitochondria is essential for normal cellular physiology and tissue development. Stimulation of mitochondrial permeabilization and release of proapoptotic factors from the intermembrane space is an essential step in triggering the mitochondrial pathway of cell death. In this study, we analyzed the extent to which mitophagy interferes with cell death, attenuating the efficiency of cancer therapy. We show that stimulation of mitophagy suppressed cisplatin-induced apoptosis, while mitophagy inhibition stimulates apoptosis and autophagy. Suppression of mitophagy involved production of reactive oxygen species, and the fate of cell was dependent on the interplay between endoplasmic reticulum stress and autophagy.
Funder
Russian Science Foundation
Publisher
Walter de Gruyter GmbH
Subject
Clinical Biochemistry,Molecular Biology,Biochemistry
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