Intracellular communication between lipid droplets and peroxisomes: the Janus face of PEX19-Reference-Cited by-同舟云学术

Intracellular communication between lipid droplets and peroxisomes: the Janus face of PEX19

Published:2018-03-03 Issue:7 Volume:399 Page:741-749
ISSN:1437-4315
Container-title:Biological Chemistry
language:en
Short-container-title:

Author:

Schrul Bianca¹,Schliebs Wolfgang²

Affiliation:

1. Medical Biochemistry and Molecular Biology, Center for Molecular Signaling (PZMS), Faculty of Medicine , Saarland University, Kirrberger Str. 100 , D-66421 Homburg/Saar , Germany

2. Institute of Biochemistry and Pathobiochemistry , Department of Systems Biochemistry, Faculty of Medicine , Ruhr University Bochum , D-44780 Bochum , Germany

Abstract

Abstract In order to adapt to environmental changes, such as nutrient availability, cells have to orchestrate multiple metabolic pathways, which are catalyzed in distinct specialized organelles. Lipid droplets (LDs) and peroxisomes are both endoplasmic reticulum (ER)-derived organelles that fulfill complementary functions in lipid metabolism: Upon nutrient supply, LDs store metabolic energy in the form of neutral lipids and, when energy is needed, supply fatty acids for oxidation in peroxisomes and mitochondria. How these organelles communicate with each other for a concerted metabolic output remains a central question. Here, we summarize recent insights into the biogenesis and function of LDs and peroxisomes with emphasis on the role of PEX19 in these processes.

Publisher

Walter de Gruyter GmbH

Subject

Clinical Biochemistry,Molecular Biology,Biochemistry

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