Biotransformation of Jatrophone by Aspergillus niger ATCC 16404-Reference-Cited by-同舟云学术

Biotransformation of Jatrophone by Aspergillus niger ATCC 16404

Published:2007-02-01 Issue:2 Volume:62 Page:275-279
ISSN:1865-7117
Container-title:Zeitschrift für Naturforschung B
language:en
Short-container-title:

Author:

Pertino Mariano¹,Schmeda-Hirschmann Guillermo¹,Santos Leonardo S.²,Rodríguez Jaime A.³,Theoduloz Cristina³

Affiliation:

1. Laboratorio de Química de Productos Naturales, Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, Talca, Chile

2. Laboratorio de Síntesis Asimétrica, Instituto de Química de Recursos Naturales, Universidad de Talca, Casilla 747, Talca, Chile

3. Laboratorio de Cultivo Celular, Facultad de Ciencias de la Salud, Universidad de Talca, Casilla 747, Talca, Chile

Abstract

Biotransformation of the diterpene jatrophone (1) by Aspergillus niger ATCC 16404 afforded the new diterpene 9β -hydroxyisabellione (2). The compounds were characterized by spectroscopic analysis. The cytotoxicity of the compounds as IC50 values on AGS and lung fibroblasts was 2.4 and 2.8 μM for compound 1 and 53.1 and 260 μM for 2, respectively. Microbial transformation of 1 into compound 2 strongly reduced the cytotoxicity and enhanced the selectivity against AGS cells.

Publisher

Walter de Gruyter GmbH

Subject

General Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/znb-2007-0221/pdf

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