Mediator structure and function in transcription initiation-Reference-Cited by-同舟云学术

Mediator structure and function in transcription initiation

Published:2023-04-21 Issue:8-9 Volume:404 Page:829-837
ISSN:1431-6730
Container-title:Biological Chemistry
language:en
Short-container-title:

Author:

Rengachari Srinivasan¹^ORCID,Schilbach Sandra¹,Cramer Patrick¹

Affiliation:

1. Department of Molecular Biology , Max Planck Institute for Multidisciplinary Sciences , Am Fassberg 11, D-37077 Göttingen , Germany

Abstract

Abstract Recent advances in cryo-electron microscopy have led to multiple structures of Mediator in complex with the RNA polymerase II (Pol II) transcription initiation machinery. As a result we now hold in hands near-complete structures of both yeast and human Mediator complexes and have a better understanding of their interactions with the Pol II pre-initiation complex (PIC). Herein, we provide a summary of recent achievements and discuss their implications for future studies of Mediator and its role in gene regulation.

Funder

Deutsche Forschungsgemeinschaft

Peter und Traudl Engelhorn Stiftung

Publisher

Walter de Gruyter GmbH

Subject

Clinical Biochemistry,Molecular Biology,Biochemistry

Link

https://www.degruyter.com/document/doi/10.1515/hsz-2023-0158/pdf

Reference58 articles.

1. Abdella, R., Talyzina, A., Chen, S., Inouye, C.J., Tjian, R., and He, Y. (2021). Structure of the human Mediator-bound transcription preinitiation complex. Science 372: 52–56, https://doi.org/10.1126/science.abg3074.

2. Aibara, S., Schilbach, S., and Cramer, P. (2021). Structures of mammalian RNA polymerase II pre-initiation complexes. Nature 594: 124–128, https://doi.org/10.1038/s41586-021-03554-8.

3. Allen, B.L. and Taatjes, D.J. (2015). The Mediator complex: a central integrator of transcription. Nat. Rev. Mol. Cell Biol. 16: 155–166, https://doi.org/10.1038/nrm3951.

4. Babokhov, M., Mosaheb, M.M., Baker, R.W., and Fuchs, S.M. (2018). Repeat-specific functions for the C-terminal domain of RNA polymerase II in budding yeast. G3 8: 1593–1601, https://doi.org/10.1534/g3.118.200086.

5. Boehning, M., Dugast-darzacq, C., Rankovic, M., Hansen, A.S., Yu, T., Marie-nelly, H., Mcswiggen, D.T., Kokic, G., Dailey, G.M., Cramer, P., et al.. (2018). RNA polymerase II clustering through carboxy-terminal domain phase separation. Nat. Struct. Mol. Biol. 25: 833–840, https://doi.org/10.1038/s41594-018-0112-y.

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