Protein transport along the presequence pathway-Reference-Cited by-同舟云学术

Protein transport along the presequence pathway

Published:2023-05-09 Issue:8-9 Volume:404 Page:807-812
ISSN:1431-6730
Container-title:Biological Chemistry
language:en
Short-container-title:

Author:

Makki Abhijith¹^ORCID,Rehling Peter¹²³⁴^ORCID

Affiliation:

1. Department of Cellular Biochemistry , University Medical Center Göttingen , D-37073 Göttingen , Germany

2. Cluster of Excellence “Multiscale Bioimaging: from Molecular Machines to Networks of Excitable Cells” (MBExC), University of Göttingen , Göttingen , Germany

3. Max Planck Institute for Multidisciplinary Sciences , D-37077 Göttingen , Germany

4. Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Translational Neuroinflammation and Automated Microscopy , Göttingen , Germany

Abstract

Abstract Most mitochondrial proteins are nuclear-encoded and imported by the protein import machinery based on specific targeting signals. The proteins that carry an amino-terminal targeting signal (presequence) are imported via the presequence import pathway that involves the translocases of the outer and inner membranes – TOM and TIM23 complexes. In this article, we discuss how mitochondrial matrix and inner membrane precursor proteins are imported along the presequence pathway in Saccharomyces cerevisiae with a focus on the dynamics of the TIM23 complex, and further update with some of the key findings that advanced the field in the last few years.

Funder

Deutsche Forschungsgemeinschaft

Publisher

Walter de Gruyter GmbH

Subject

Clinical Biochemistry,Molecular Biology,Biochemistry

Link

https://www.degruyter.com/document/doi/10.1515/hsz-2023-0133/pdf

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