Influence of phosphorylation on intermediate filaments

Author:

Kraxner Julia12,Köster Sarah34ORCID

Affiliation:

1. Max Delbrück Center for Molecular Medicine , Robert-Rössle-Straße 10 , D-13125 Berlin , Germany

2. German Centre for Cardiovascular Research (DZHK) , Partner Site Berlin , D-10785 Berlin , Germany

3. University of Göttingen, Institute for X-Ray Physics , Friedrich-Hund-Platz 1 , D-37077 Göttingen , Germany

4. German Center for Cardiovascular Research (DZHK) , Partner Site Göttingen , D-37075 Göttingen , Germany

Abstract

Abstract The cytoskeleton of eukaryotes consists of actin filaments, microtubules and intermediate filaments (IF). IFs, in particular, are prone to pronounced phosphorylation, leading to additional charges on the affected amino acids. In recent years, a variety of experiments employing either reconstituted protein systems or living cells have revealed that these altered charge patterns form the basis for a number of very diverse cellular functions and processes, including reversible filament assembly, filament softening, network remodeling, cell migration, interactions with other protein structures, and biochemical signaling.

Funder

Deutsche Forschungsgemeinschaft

H2020 European Research Council

Publisher

Walter de Gruyter GmbH

Subject

Clinical Biochemistry,Molecular Biology,Biochemistry

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