Why do certain cancer cells alter functionality and fuse?
Author:
Dittmar Thomas1ORCID, Sieler Mareike1, Hass Ralf2ORCID
Affiliation:
1. Institute of Immunology, Center for Biomedical Education and Research (ZBAF), Witten/Herdecke University , Stockumer Str. 10, D-58448 Witten , Germany 2. Department of Obstetrics and Gynecology , Biochemistry and Tumor Biology Laboratory, Hannover Medical School , D-30625 Hannover , Germany
Abstract
Abstract
Cancer cell fusion represents a rare event. However, the surviving cancer hybrid cells after a post-hybrid selection process (PHSP) can overgrow other cancer cells by exhibiting a proliferation advantage and/or expression of cancer stem-like properties. Addition of new tumor properties during hetero-fusion of cancer cells e.g. with mesenchymal stroma-/stem-like cells (MSC) contribute to enhanced tumor plasticity via acquisition of new/altered functionalities. This provides new avenues for tumor development and metastatic behavior. Consequently, the present review article will also address the question as to whether cancer cell fusion represents a general and possibly evolutionary-conserved program or rather a random process?
Funder
Niedersächsische Krebsgesellschaft interne Forschungsförderung Witten/Herdecke University
Publisher
Walter de Gruyter GmbH
Subject
Clinical Biochemistry,Molecular Biology,Biochemistry
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