Der 2,4,6-Triisopropylbenzolsulfonyl(Tip)-Rest, eine neue Schutzgruppe für die Guanidinofunktion von Arginin / The 2,4,6-Triisopropylbenzenesulfonyl Residue, a New Protecting Group for the Guanidino Function of Arginine

Abstract

Abstract The 2.4.6-triisopropylbenzenesulfonyl group is introduced in high yield into the guanidino function of arginine by the reaction of Na-protected arginine with 2.4.6-triisopropylbenzene-sulfonyl chloride. This protecting group was found to be cleaved by commonly used reagents used in peptide synthesis like methanesulfonic, trifluoromethanesulfonic acid or mixtures of tri-fluoroacetic with methanesulfonic or trifluoromethanesulfonic acid.