Biopolymeric matrices based on chitosan for medical applications

Abstract

AbstractChitosan (CS) based materials in a form of composite with poly(lactic acid) (PLA) granules, films and freeze-dried scaffolds also with blend form with hydroxypropylocellulose (HPC), as well as dibutyrylchitin films were obtained. These structures are intended especially for controlled drug delivery systems, including transdermal and oral dosage forms. Excellent adhesion of biopolymer matrices to PLA microspheres or hydroxyapatite (HAp) particles was proven. The Iorder drug (ibuprofen (IBU)) release kinetics from obtained films is stated.