The perinatal factors that influence the excretion of fecal calprotectin in premature-born children-Reference-Cited by-同舟云学术

The perinatal factors that influence the excretion of fecal calprotectin in premature-born children

Published:2022-01-01 Issue:1 Volume:17 Page:1275-1281
ISSN:2391-5463
Container-title:Open Medicine
language:en
Short-container-title:

Author:

Cekovic Jelena R.¹,Prodanovic Nikola S.²³,Mijailovic Sara S.⁴,Knezevic Sanja M.⁵⁶,Vuletic Biljana P.⁵⁷,Stojkovic Andjelka K.⁵⁸,Savic Dragana M.¹⁵,Prodanovic Tijana V.¹,Stanojevic Marina M.⁹,Simovic Aleksandra M.¹⁵

Affiliation:

1. Neonatal Intensive Care Unit, Center for Neonatology, Pediatric Clinic, University Clinical Centre Kragujevac , Kragujevac , Serbia

2. Department of Alloartoplastic Surgery, Clinic for Orthopedics and Traumatology, University Clinical Center Kragujevac , 34000 Kragujevac , Serbia

3. Department of Surgery, Faculty of Medical Sciences, University of Kragujevac , Svetozara Markovica 69 , 34000 Kragujevac , Serbia

4. Department of Medical Statistics and Informatics, Faculty of Medical Sciences, University of Kragujevac , Kragujevac , Serbia

5. Department of Pediatrics, Faculty of Medical Sciences, University of Kragujevac , Kragujevac , Serbia

6. Department of Cardiology, Pediatric Clinic, University Clinical Centre Kragujevac , Kragujevac , Serbia

7. Department of Gastroenterology, Pediatric Clinic, University Clinical Centre Kragujevac , Kragujevac , Serbia

8. Department of Pulmonology, Pediatric Clinic, University Clinical Centre Kragujevac , Kragujevac , Serbia

9. Department of Neonatology, Clinic for Gynecology and Obstetrics, University Clinical Centre Kragujevac , Kragujevac , Serbia

Abstract

Abstract This study aimed to provide additional information on the influence of perinatal factors on fecal (f)-calprotectin values in preterm infants. Calprotectin was determined from the first spontaneous stool (analyzed on the Alegria device by using the enzyme-linked immunosorbent assay [ELISA] method) obtained from neonates at a mean age of 3.41 ± 2.44 days of life. We analyzed 114 subjects who had a body weight of 1847.67 ± 418.6 g and were born at a gestational age of 32.6 ± 2.43 weeks, without intestinal and other congenital anomalies or any diseases other than those related to premature birth. The values of f-calprotectin are in a positive correlation with female subjects, intrauterine growth restriction, significant ductus arteriosus, enteral feeding intolerance, postnatal prolonged use of broad-spectrum antibiotics, and values of bicarbonates (analyzed in a sample of capillary arterial blood). Measurement of f-calprotectin in the first 7 days after birth can help to early detect the intestinal distress or early staging of necrotizing enterocolitis in premature infants.

Publisher

Walter de Gruyter GmbH

Subject

General Medicine

Link

https://www.degruyter.com/document/doi/10.1515/med-2022-0522/pdf

Reference37 articles.

1. Rougé C, Butel MJ, Piloquet H, Ferraris L, Legrand A, Vodovar M, et al. Fecal calprotectin excretion in preterm infants during the neonatal period. PLoS One. 2010;5(6):e11083. 10.1371/journal.pone.0011083. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884033/pdf/pone.0011083.pdf.

2. Kapel N, Campeotto F, Kalach N, Baldassare M, Butel MJ, Dupont C. Faecal calprotectin in term and preterm neonates. J Pediatr Gastroenterol Nutr. 2010;51(5):542–7. 10.1097/MPG.0b013e3181e2ad72. https://journals.lww.com/jpgn/Fulltext/2010/11000/Faecal_Calprotectin_in_Term_and_Preterm_Neonates.2.aspx.

3. Lisowska-Myjak B, Skarzynska E, Zytynska-Daniluk J. Calprotectin in serially collected meconium portions as a biomarker for intrauterine fetal environment. Fetal Diagn Ther. 2018;43:68–71. 10.1159/000472150.

4. Goldstein PG, Sylvester KG. Biomarker discovery and utility in necrotizing enterocolitis. Clin Perinatol. 2019;46:1–17. 10.1016/j.clp.2018.10.001.

5. Lopez RN, Leach ST, Lemberg DA, Duvoisin G, Gearry RB, Day AS. Fecal biomarkers in inflammatory bowel disease. J Gastroenterol Hepatol. 2017;32(3):577–82. 10.1111/jgh.13611. https://onlinelibrary.wiley.com/doi/epdf/10.1111/jgh.13611.