Affiliation:
1. 1Faculty of Pharmacy, Department of Pharmaceutical Organic Chemistry, University of Mansoura, Mansoura 35516, Egypt
Abstract
AbstractNew pyrazoles have been synthesized and evaluated as breast cancer cell growth inhibitors. Condensation of the substituted pyrazole-4-carbaldehyde1with acetophenone and chloroacetophenone afforded α, β-unsaturated ketones2and3, respectively. Compounds2and3were subjected to different reactions using hydrazine hydrate, substituted hydrazine hydrate, hydroxylamine,o-phenylenediamine, malononitrile under different conditions affording 4-substituted pyrazole derivatives4–28. Structure elucidation of these compounds was conducted using IR,1H NMR,13C NMR, mass spectral data and elemental analysis. Antitumor activity of target compounds was tested against MCF-7 cell line (human breast cancer). Compounds4,10and20show significant antitumor activity against breast cancer. Docking was performed with protein 1UYK to study the binding mode of the designed compounds.
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