Efficient synthesis of 3-(bromomethyl)-5-methylpyridine hydrobromide-Reference-Cited by-同舟云学术

Efficient synthesis of 3-(bromomethyl)-5-methylpyridine hydrobromide

Published:2015-08-01 Issue:4 Volume:21 Page:203-205
ISSN:2191-0197
Container-title:Heterocyclic Communications
language:
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Author:

Guo Jianyu¹,Lu Yan²,Wang Jin²

Affiliation:

1. 1Department of Chemistry, Shanghai Normal University, Shanghai 200234, China

2. 2School of Chemical and Environmental, Shanghai Institute of Technology, Shanghai 201418, China

Abstract

Abstract5-Methyl-3-(bromomethyl)pyridine is the key intermediate in the synthesis of rupatadine. In this article, a new preparation of 5-methyl-3-(bromomethyl)pyridine hydrobromide is reported, which used 5-methylnicotinic acid as the starting material, with a 65.9% overall yield. This method has the merits of being simple, efficient and environmentally friendly.

Publisher

Walter de Gruyter GmbH

Subject

Organic Chemistry

Link

https://www.degruyter.com/document/doi/10.1515/hc-2015-0107/pdf

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