Catalyst-free tandem Knoevenagel-Michael reaction of aldehydes and pyrazolin-5-one: fast and convenient approach to medicinally relevant 4,4′-(arylmethylene)bis(1H-pyrazol-5-ol)s

Author:

Elinson Michail N.,Sokolova Olga O.,Nasybullin Ruslan F.

Abstract

AbstractCatalyst-free tandem Knoevenagel-Michael reaction of aryl aldehydes and two equivalents of 3-methyl-1-phenyl-2-pyrazolin-5-one results in fast (5 min) formation of medicinally relevant 4,4′-(arylmethylene)bis(1

Publisher

Walter de Gruyter GmbH

Subject

Organic Chemistry

Reference54 articles.

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2. Synthesis and antifungal activity of some arylmethylene derivatives of substituted pyrazolones;Singh;Indian Chem Soc,1991

3. An prolin - grafted mesoporous silica with alternating hydrophobic and hydrophilic blocks to promote direct asymmetric aldol and Knoevenagel Michael cascade reactions;Guo;Catal,2014

4. The current status of heterocyclic combinatorial libraries;Nefzi;Chem Rev,1997

5. acid silicapropyl sulfanyl propyl ester as a recyclable catalyst for the synthesis of arylmethylene bis methyl phenyl pyrazol ols;Tayebi;Catal,2011

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