Metallation of Ligands with Biological Activity: Synthesis And X-Ray Characterization of [(SDAZ)2Au2(dppe)] (SDAZ = Sulphadiazinide Anion; dppe = 1,2-Bis(diphenylphosphanyl)ethane)

Abstract

Sulphadiazine, [4-amino-N-(2-pyrimidinyl)-benzenesulfonamide], reacts with (dppe)Au2Cl2 and triethylamine in methanol to produce [(SDAZ)2Au2(dppe)]. The structure of this novel complex was analyzed by single crystal X-ray diffraction. In [(SDAZ)2Au2(dppe)] the ligands SDAZ− and dppe have approximately the same bond distances and angles as found for the protonated and free ligand, respectively. The compound is assembled essentially of two gold atoms bonded to the phosphorus centers of one 1,2-bis(diphenylphosphanyl)ethane molecule (in an anti conformation). The coordination sphere is completed with a trans sulphadiazine ligand on each gold atom. Because of their fairly high reactivity, the two aromatic amine groups in the SDAZ ligands represent important sites for the chemical modification of the complex with biological purposes