Bioactive Phenylethanoid Glycosides from Buddleia lindleyana

Abstract

Nine phenylethanoid glycosides were isolated from Buddleia lindleyana. On the basis of spectral analyses, their structures were elucidated to be acteoside (1), echinacoside (2), citanoside A (3), leucosceptoside A (4), leucosceptoside B (5), pedicularioside A (6), isoacteoside (7), arenariside (8), and a new compound named buddleoside A (9). The eight known compounds were isolated from this plant for the first time. The neuroprotective effects of compounds 1 (acteoside), 5, 6, 8 and 9 on the 1-methyl-4-phenylpyridinium ion (MPP+)-induced cell death in mesencenphalic neurons were investigated. Mesencenphalic neurons treated with MPP+ underwent cell death as determined by MTT assay. Simultaneous treatment with the phenylethanoid glycosides markedly attenuated MPP+- induced cytotoxicity.