An application of citric acid as a carrier for solid dispersion to improve the dissolution and uric acid-lowering effect of kaempferol
Author:
Song Danni1, Xie Changqing2, Yang Rong2, Ma Aijinxiu2, Zhao Honghui2, Zou Fengmao1, Zhang Xiangrong2, Zhao Xu2ORCID
Affiliation:
1. School of Traditional Chinese Material Medica , Shenyang Pharmaceutical University , Shenyang 110016 , China 2. Faculty of Functional Food and Wine , Shenyang Pharmaceutical University , Shenyang 110016 , China
Abstract
Abstract
Kaempferol (KPF) is a flavonoid compound, which has a variety of pharmacological activities, and widely exists in daily diet. However, its application is limited due to poor solubility. Citric acid (CA) is a common food additive with high solubility. In this study, solid dispersion (SD) was prepared with CA as the carrier to improve the solubility of KPF. KPF-CA-SD (weight ratio 1:20) was obtained by ultrasonic for 20 min at 40 °C. The in vitro dissolution of KPF in SD was increased from about 50% to more than 80%. The physicochemical characterizations were analyzed by X-ray diffraction, differential scanning calorimetry, Fourier transform infrared spectroscopy, and scanning electron microscope. In hyperuricemia mice, KPF-SD (equivalent to 100 mg/kg KPF) can effectively reduce serum uric acid and exert nephroprotective effects. In conclusion, the preparation of SD with CA might provide a safe and effective selection to facilitate application of KPF in food and medicine.
Funder
Young and Middle Aged Teachers’ Career Development Support Project of Shenyang Pharmaceutical University Livelihood Plan Project of Department of Science and Technology of Liaoning Province Department of Education of Liaoning Province
Publisher
Walter de Gruyter GmbH
Subject
Engineering (miscellaneous),Food Science,Biotechnology
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