Quantitative visualization study on the physical movement and gastric emptying of diced carrot particle in a transparent rat stomach-duodenum model

Abstract

Abstract In this study, a transparent soft-elastic silicone rat stomach model was prepared to visualize the gastric movement and emptying of one individual diced carrot in a dynamic in vitro rat stomach system. The influences of the viscosity of solution medium, the pattern of gastric peristalsis and the extraction rate of the emptying pump on the location and gastric residence time of the carrot particle were examined. A proper medium viscosity could promote the emptying of the carrot particle. Compared to the combined actions of plate and roller, gastric residence time of the carrot particle was reduced from 32.3 to 19.8 min under the single plate compression. This time was also shortened from 34.8 to 12.3 min when the extraction rate of emptying pump was changed from 100 mL/min to 400 mL/min. Knowledge gained from this work is unique and may provide new insights for optimizing biomimic gastrointestinal models.