Organic biocides hosted in layered double hydroxides: enhancing antimicrobial activity

Abstract

AbstractSamples of layered double hydroxides containing carbonates as compensating anions were prepared by the urea method. These LDHs were used as hosts of anions coming from pipemidic and nalidixic acid. XRD results confirm that these anions were hosted in the interlayer space of LDHs. Further, from27Al NMR MAS characterization of an interaction between the brucite-like layers and anions was suggested. Then the hybrids LDHs were used as biocide ofSalmonella typhiandEscherichia coli. The release profile of pipemidic and nalidixic anions from hybrid LDHs occurs for periods as long as 3.5 hours. The free-organic acid LDHs were not able to killS.Typhi, neitherE.coli. In contrast, the hybrids LDHs eliminate almost completely bacteria within short times.