Two novel haemoglobin variants that affect haemoglobin A1c measurement by ion-exchange chromatography

Author:

Bots Michael,Stroobants An K.,Delzenne Barend,Soeters Maarten R.,de Vries Johan E.,Weykamp Cas W.,Norg Roelf J.C.,Veldthuis Martijn,Zwieten Rob van

Abstract

AbstractHaemoglobin (Hb) variants are well-known factors interfering with accurate HbAGlycated forms of novel Hb variants were recognised in the blood of two patients with diabetes mellitus screened by HbAA fraction of 15% of abnormal Hb was observed in a 37-year-old female. DNA sequencing revealed a heterozygous mutation in the αClose examination of HbA

Publisher

Walter de Gruyter GmbH

Subject

Biochemistry (medical),Clinical Biochemistry,General Medicine

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