Author:
Larosa Maria del Pilar,Mackenzie Rachel,Burne Peter,Garelli Silvia,Barollo Susi,Masiero Stefano,Rubin Beatrice,Chen Shu,Furmaniak Jadwiga,Betterle Corrado,Smith Bernard Rees
Abstract
AbstractBackground:Measurements of autoantibodies to interferon-ω (IFN-ω) in patients with autoimmune polyglandular syndrome type 1 (APS-1) were performed using a new immunoprecipitation assay (IPA) based onMethods:We have developed and validated a new IPA based onResults:Sixty-six (84.6%) of 78 APS-1 patients were positive for IFN-ω Ab usingConclusions:We have developed a novel, highly sensitive and specific assay for measurement of IFN-ω Ab. It provides a simple and convenient method for the assessment of patients with APS-1 and selecting patients suspected of having APS-1 for
Subject
Biochemistry (medical),Clinical Biochemistry,General Medicine
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