ABO blood group: old dogma, new perspectives

Author:

Franchini Massimo1,Liumbruno Giancarlo Maria2

Affiliation:

1. Department of Transfusion Medicine and Hematology, Azienda Ospedaliera Carlo Poma , Mantova , Italy

2. Immunohematology, Transfusion Medicine and Clinical Pathology Units, “San Giovanni Calibita” Fatebenefratelli Hospital, AFAR , Rome , Italy

Abstract

Abstract Human blood group antigens are glycoproteins and glycolipids expressed on the surface of red blood cells and a variety of human tissues, including the epithelium, sensory neurons, platelets and the vascular endothelium. Accumulating evidence indicate that ABO blood type is implicated in the development of a number of human diseases, including cardiovascular and neoplastic disorders. In this review, beside its physiologic role in immunohematology and transfusion medicine, we summarize the current knowledge on the association between the ABO blood group and the risk of developing thrombotic events and cancers.

Publisher

Walter de Gruyter GmbH

Subject

Biochemistry (medical),Clinical Biochemistry,General Medicine

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