Author:
Solecki Kamila,Dupuy Anne Marie,Kuster Nils,Leclercq Florence,Gervasoni Richard,Macia Jean-Christophe,Cung Thien-Tri,Lattuca Benoit,Cransac Frédéric,Cade Stéphane,Pasquié Jean-Luc,Cristol Jean-Paul,Roubille François
Abstract
AbstractCardiac biomarkers are the cornerstone of the biological definition of acute myocardial infarction (AMI). The key role of troponins in diagnosis of AMI is well established. Moreover, kinetics of troponin I (cTnI) and creatine kinase (CK) after AMI are correlated to the prognosis. New technical assessment like high-sensitivity cardiac troponin T (hs-cTnT) raises concerns because of its unclear kinetic following the peak. This study aims to compare kinetics of cTnI and hs-cTnT to CK in patients with large AMI successfully treated by percutaneous coronary intervention (PCI).We prospectively studied 62 patients with anterior AMI successfully reperfused with primary angioplasty. We evaluated two consecutive groups: the first one regularly assessed by both CK and cTnI methods and the second group by CK and hs-cTnT. Modeling of kinetics was realized using mixed effects with cubic splines.Kinetics of markers showed a peak at 7.9 h for CK, at 10.9 h (6.9–12.75) for cTnI and at 12 h for hs-cTnT. This peak was followed by a nearly log linear decrease for cTnI and CK by contrast to hs-cTnT which appeared with a biphasic shape curve marked by a second peak at 82 h. There was no significant difference between the decrease of cTnI and CK (p=0.63). CK fell by 79.5% (76.1–99.9) vs. cTnI by 86.8% (76.6–92.7). In the hs-cTnT group there was a significant difference in the decrease by 26.5% (9–42.9) when compared with CK that fell by 79.5% (64.3–90.7).Kinetic of hs-cTnT and not cTnI differs from CK. The role of hs-cTnT in prognosis has to be investigated.
Subject
Biochemistry (medical),Clinical Biochemistry,General Medicine
Reference80 articles.
1. AS HD Third universal definition of myocardial infarction;Thygesen;Eur Heart J,2012
2. Comparison of the prognostic value of peak creatine kinase - MB and troponin levels among patients with acute myocardial infarction : a report from the Acute Coronary Treatment and Intervention Outcomes Network Registry get with the guidelines;Chin;Clin Cardiol,2012
3. DA AB National of Biochemistry Laboratory Medicine Practice Guidelines : clinical characteristics and utilization of biochemical markers in acute coronary syndromes;Morrow;Academy Clinical Clin Chem,2007
4. Relationship between TIMI frame count and clinical outcomes after thrombolytic administration Thrombolysis In Myocardial Study Group;Gibson;Circulation,1999
5. Relationship between TIMI frame count and clinical outcomes after thrombolytic administration Thrombolysis In Myocardial Study Group;Gibson;Circulation,1999
Cited by
39 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献